Table 1.
Synthetic genetic interactions of yta7∆ with mutations in genes encoding kinetochore components
| Kinetochore component/complex | Human homolog* | Allele | Synthetic phenotype with yta7Ơ |
| CENP-A | CENP-A | cse4-103 | Slight enhancement of growth defect |
| CENP-C | CENP-C | mif2-3 | Enhanced growth defect |
| Cbf1 | — | cbf1∆ | Growth defect |
| COMA complex | CENP-Q | okp1-5 | Suppression of growth defect |
| CENP-U | ame1-4 | Suppression of growth defect | |
| CENP-P | ctf19∆ | Growth defect | |
| CENP-O | mcm21∆ | Growth defect | |
| Ctf19 complex | CENP-L | iml3∆ | Growth defect |
| CENP-N | chl4∆ | Growth defect | |
| CENP-I | ctf3∆ | Slight growth defect | |
| CENP-H | mcm16∆ | Slight growth defect | |
| CENP-K | mcm22∆ | Slight growth defect | |
| CENP-T | cnn1∆ | Slight growth defect | |
| CENP-W | wip1∆ | Slight growth defect | |
| — | nkp1∆ | — | |
| — | nkp2∆ | — | |
| Mtw1/MIND complex | Mis12 | mtw1-11 | — |
| PMF1 | nnf1-77 | — | |
| Dsn1 | dsn1-7, dsn1-8 | — | |
| NSL1 | nsl1-5, nsl1-6 | — | |
| Ndc80 complex | NDC80 | ndc80-1 | Slight enhancement of growth defect |
| NUF2 | nuf2-61 | Slight enhancement of growth defect | |
| SPC24 | spc24-1 | Slight enhancement of growth defect | |
| SPC25 | spc25-1 | Partial suppression of growth defect | |
| Knl1 complex | KNL1 | spc105-4 | Slight enhancement of growth defect |
| CBF3 complex | — | ctf13-3 | Partial suppression of growth defect |
| — | cep3-1, cep3-2 | Partial suppression of growth defect | |
| — | ndc10-1 | — | |
| — | ndc10-2 | Partial suppression of growth defect |
*
A dash (—) indicates no known homolog.
†
The combined defect of yta7∆ with the indicated mutations is given. A dash (—) indicates that yta7∆ does not affect the growth phenotype of the respective other mutation.