Modifications at the Cu(II) coordination site and small molecules studied in this work. (A) Chemical modifications obtained from the reaction of Cu(II)–Aβ with L1. (B) Chemical structures of L1 [N1,N1-dimethyl-N4-(thiophen-2-ylmethyl)benzene-1,4-diamine], L2 [N,N-dimethyl-4-((thiophen-2-ylmethyl)thio)aniline], and L3 [N,N-dimethyl-4-((pyridin-2-ylmethyl)thio)aniline].