Fig. 5.

Regulation of the toxicity triggered by Cu(II)-treated Aβ₄₀ and metal-free Aβ₄₀ by L1 and other metal chelators (i.e., EDTA and phen) in living cells. (A) Scheme of the cell viability experiments. (B) Survival of the cells treated with Cu(II)-added Aβ₄₀ and metal-free Aβ₄₀ that were preincubated with L1, EDTA, and phen. Cell viability, determined by the MTT assay, was calculated in comparison to that with an equivalent amount of DMSO. Conditions were as folows: [Aβ₄₀], 10 μM, [CuCl₂], 10 μM, [compound], 10 μM. *P < 0.05 by Student’s t test.