Fig. 6.

IFN-λ promotes skin inflammation. (A) H&E staining and (B) pathology scoring of ear skin in murine lupus. Tissue sections were prepared after 5 wk of IMQ treatment (n = 8 untreated, n = 8 WT + IMQ, n = 7 Ifnlr1^−/− + IMQ). (C–F) Inflammatory cytokine and chemokine expression in murine lupus skin. Gene expression was measured in ear tissue after 5 wk of IMQ treatment by qPCR (n = 8 untreated, n = 16 WT + IMQ, n = 12 Ifnlr1^−/− + IMQ). Data were normalized to untreated mice. Data are represented as mean ± SEM. Statistics were calculated by one-way ANOVA with Tukey’s correction for multiple comparisons or nonparametric Mann–Whitney U test. *P < 0.05, ****P < 0.0001; ns, not significant.