Table 1.
List of genes most commonly associated across GWAS of alcohol consumption and/or abuse. Studies are included if they demonstrate an association with the SNP denoted in the table, or with a SNP in LD (r2 > 0.6). Of note, the proximity of the listed SNPs to the nearest gene does not prove that the gene is causal.
| Chromosome | Nearest gene | SNP | Alcohol consumption | Alcohol abuse / AUD | References |
|---|---|---|---|---|---|
| 2 | GCKR | rs1260326 | Y | Y | (17, 18, 21–23) |
| 4 | KLB | rs11940694 | Y | (15, 17, 21–23) | |
| 4 | KLB | rs35538052 | Y | (18, 21) | |
| 4 | ADH1B | rs1229984 | Y | Y | (12, 17, 18, 21–23) |
| 4 | SLC39A8 | rs13107325 | Y | Y | (17, 18, 21, 22) |
| 2 | LINC01833 | rs1004787 | Y | Y | (17, 18, 21) |
| 17 | MAPT/CHRH1 | rs62062288 | Y | Y | (17, 21, 22) |
| 19 | IZUMO/FGF21 | rs281379 | Y | Y | (17, 21, 22) |
| 16 | FTO | rs35538052 | Y | (17, 18) | |
| 4 | ADH1C | rs142783062 | Y | Y | (17, 18) |
| 3 | CADM2 | rs62250685 | Y | (21, 23) |