Figure 4. RBM4 is required for ERBB1 protein upregulation during hypoxia.
A RBM4 transcript levels after knockdown of RBM4 (n≥5 per group). B RBM4 protein levels after knockdown of RBM4. One representative blot from three independent experiments is shown. C ERBB1 protein levels in Nx and Hx; β-ACTIN was used as a loading control. One representative blot from three independent experiments is shown. D Densitometry of ERBB1 western blots (n=4 per group). *p<0.05, ***p<0.001, n.s., nonsignificant. Data are presented as the mean ± SD. A unpaired, two-tailed t-test. D Two-way ANOVA and Bonferroni adjustment for comparisons between Nx and Hx. A t=12.56, df=9 D F3,12=12.32, p<0.001