. Author manuscript; available in PMC: 2021 Mar 13.

Published in final edited form as: ACS Infect Dis. 2020 Jan 24;6(3):393–405. doi: 10.1021/acsinfecdis.9b00354

Table 1:

Most active compounds identified in this study

Compound	CID	Structure	TGR IC₅₀ (μM)		Adult worms			Sm^║ juvenile	Sm^║ Somula
Compound	CID	Structure	qHTS^†	Confirm	Sm^║	Sj^║	Sh^║	Sm^║ juvenile	Sm^║ Somula
1	3561200		n. d.^*	0.33	10 μM 120 h 62% d^‡	10 μM 120 h 65% d^‡	10 μM 144 h 67% d^‡	10 μM 120 h 39% d^‡	10 μM 24 h 99% d^‡
2	16012863		0.3981	0.21	10 μM 120 h 78% d^‡	10 μM 120 h 50% d^‡	10 μM 120 h 94% d^‡	10 μM 24 h 100% d^‡	10 μM 24 h 100% d^‡
3	4412151		6.3^{^}	2.84	10 μM 72 h 100% d^‡	10 μM 120 h 70% d^‡	10 μM 96 h 100% d^‡	10 μM 48 h 100% d^‡	10 μM 24 h 100% d^‡
4^€	2779853		5.438^{^}	2.01	10 μM 144 h 76% d^‡	10 μM 120 h 69% d^‡	10 μM 120 h 85% d^‡	10 μM 72 h 100% d^‡	10 μM 24 h 100% d^‡
5^&	2801235		0.1	0.06	10 μM 120 h 67% d^‡	10 μM 120 h 30% d^‡	10 μM 120 h 48% d^‡	10 μM 120 h 57% d^‡	10 μM 24 h 100% d^‡
6	659226		0.631	0.14	12.5 μM 120 h 28% d^‡	12.5 μM 120 h 100% d^‡	n. d.^*	12.5 μM 120 h 100% d^‡	12.5 μM 120 h 96% d^‡
7	1090309		0.3162	0.09	12.5 μM 120 h 43% d^‡	12.5 μM 120 h no killing	n. d.^*	12.5 μM 120 h 8% d^‡	12.5 μM 120 h 61% d^‡
8	2943813		0.3981	0.13	12.5 μM 120 h 53% d^‡	12.5 μM 120 h 56% d^‡	n. d.^*	10 μM 120 h 24% d^‡	10 μM 120 h 20% d^‡

^€

Also known as Stattic;²⁷

also known as TRi-1;²⁶

^†

AID485364;

not determined;

^{^}

Li et al. 2015;¹⁸

^║

Sm - Schistosoma mansoni, Sj - S. japonicum, Sh - S. haematobium;

^‡

- dead