4. Evaluation of diagnostic efficacy of PGC and MG7 proteins in GC.

Gastric diseases	Biomarker	Sensitivity (%)	Specificity (%)	YD	AUC	P*
*, for AUC; PGC, pepsinogen C; GC, gastric cancer; AG, atrophic gastritis; YD, Youden index; AUC, area under the curve.
GC	PGC≤2	96.1	70.2	0.663	0.837	<0.001
	MG7≥3	87.0	78.4	0.654	0.892	<0.001
	D type	92.2	78.8	0.711	−	<0.001
AG+GC	PGC≤2	97.2	82.9	0.801	0.943	<0.001
	MG7≥2	89.0	85.0	0.740	0.911	<0.001
	D type	77.2	97.9	0.751	−	<0.001