Table 3.
Variability and reliability of test-retest parameters from 10 healthy volunteers after injection of [18F]LSN3316612
| Parametera | Source | Testb | Retestb | TRV (%) | aTRV (%) | ICC |
|---|---|---|---|---|---|---|
| VT | Brain and plasma | 13.7 (19.2) | 15.3 (19.6) | 11.3 | 12.5 | 0.64 |
| AUC150–180 | Brain | 102.2 (16.3) | 103.6 (11.9) | 1.8 | 9.0 | 0.68 |
| AUC/CP150–180 | Brain and plasma | 654.1 (46.2) | 661.1 (19.7) | 6.5 | 31.9 | 0.18 |
|
Plasma parent AUC0–∞ |
Plasma | 105.9 (20.3) | 96.0 (20.3) | − 9.7 | 12.3 | 0.69 |
|
Brain AUC0–∞ |
Brain | 1428.2 (23.3) | 1445.5 (20.6) | 1.6 | 13.3 | 0.78 |
TRV test-retest variability, aTRV absolute test-retest variability, ICC intraclass correlation coefficient, VT total distribution volume, AUC area under the curve, TAC time-activity curve
aThe measured parameters were VT total distribution volume (mL·cm−3); AUC150–180 area under the curve of brain TAC of 150–180 min; AUC/CP150–180 normalized AUC150–180 to mean parent radioactivity concentration in arterial plasma; AUC0–∞ area under the curve estimated from 0 min to infinity
bData are presented as mean with coefficient of variation (%) in parentheses