Figure 3.

Print screen of the Ensembl genome browser presenting a part of the variant table of the PPARG gene. The table includes seven selected sequence variants and results of bioinformatics prediction of their effect on protein function. Ensembl browser includes six tools for predicting effects of substitutions on protein function: SIFT, PolyPhen, CADD. REVEL, MetaLR, and Mutation Assessor. Predicted effect on protein function is shown in different colors: benign: green; tolerated/neutral: blue; possibly damaging: orange; damaging: red. Clin. Sig.: clinical significance; a classification of a variant's impact on disease, according to the ClinVar database: pathogenic: red triangle; likely pathogenic: orange triangle; likely benign: blue cross.