Table 3.

Molecular changes in cellular model of osteoarthritis.

Authors (year)	Cell line	Treatment	Findings
Xu et al. (2015) [26]	SW1353	100 ng/ml human TNF-α for 0, 6, 12, 24, 36, and 48 h	↑ Cleaved caspase-3, cleaved PARP, Sam68, MMP-13, ADAMTS-5, iNOS, and IL-6 ↓ IκBα, ↑ p-p65
Yu et al. (2018) [27]	CHON-001 (human chondrocyte cell)	IL-1β (0.1 ng/ml, 2 ng/ml, 5 ng/ml, and 10 ng/ml)	↑ miR-126, IL-6, IL-8, and TNF-α
Jiang et al. (2017) [28]	SW1353	10 ng/ml IL-1β	↑ IL-6, IL-8, IL-10, TNF-α, MMP-2, MMP-3, MMP-9, MMP-13, BRD4, HMGB1, and nuclear p65
Sun et al. (2017) [29]	ATDC5 (murine articular chondrocyte)	LPS (0, 1, 5, and 10 μg/ml) for 6 hrs	↑ miR-146a, IL-1β, IL-6, IL-8, and TNF-α ↓ CXCR4
Tao et al. (2015) [96]	SW1353 (human chondrosarcoma cells)	10 ng/ml IL-1β for 0, 12, 24, 36, and 48 hrs respectively	↑ KPNA2, MMP-13, and ADAMTS-5 ↑ Nuclear p65, p-p65
Blaney Davidson et al. (2015) [97]	H4 (murine chondrocyte), G6 (human chondrocyte)	IL-1β (1 or 10 ng/ml) or TGF-β1 (0.1, 1, or 10 ng/ml)	↑ NGF