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CDKI-73 reduces pro-inflammatory cytokine release by human THP-1 macrophages. (a–d) Comparative histograms showing the secretion of IL-1β (a), IL-6 (b), IL-8 (c) and TNFα (d) from lipopolysaccharide (LPS)-stimulated THP-1 macrophages after the addition of CDKI-73 compound. One-way ANOVA and Tukey’s multiple comparison test showed significant differences between the means in designated groups (depicted by different letters on the bars, p < 0.0001). Data are represented as mean ± SEM.
