Table 1.
Human BCR-ABL transcripts and proteins. The name and composition of the various human BCR-ABL hybrid transcripts identified in patients are described. The size of the corresponding proteins, their frequency of detection, and the cell lines expressing them are also indicated.
| BCR-ABL mRNA | Size of the Corresponding Protein (kDa) | Examples of CML Cell Lines | References | ||
|---|---|---|---|---|---|
| Hybrid mRNA Name | Composition | ||||
| BCR Exons $ | ABL Exons £ | ||||
| e13a2 or b2a2 | 1–13 | 2–11 | 210 | MEG-01, KBM-7, KYO-1, CML-T1, KCL-22 | [12,13,14,15] |
| e14a2 or b3a2 | 1–14 | 2–11 | 210 | K-562, KBM-5, LAMA-84, EM-3, TK-6, EM-2 | [12,13,15,16] |
| e13a3 or b2a3 | 1–13 | 3–11 | 210 | NA | [17] |
| e14a3 or b3a3 | 1–14 | 3–11 | 210 | NA | [17] |
| e18a2 | 1–18 | 2–11 | 225 | AR-230 | [13,18] |
| e19a2 | 1–19 | 2–11 | 230 | AR-230 | [13,17] |
| e1a2 | 1 | 2–11 | 190 | SUP-B15 *, Z-33 *, SD-1 *, TOM-1 *, Z-119 * | [13,14] |
| e6a2 | 1–6 | 2–11 | 185 | NA | [19] |
$ Of the 23 exons that compose the BCR gene. £ Of the 11 exons that compose the ABL gene. * Acute lymphocytic leukemia cell lines. ABL: Abelson; BCR: breakpoint cluster region; NA: not applicable.