Table 6.

Proteins that interact directly with the HDAC6 protein.

Protein Inhibiting HDAC6 by Direct Interaction	Protein Function	Protein Region Required for Interaction with HDAC6	HDAC6 Domain Interacting with the Protein	Cellular Impact	References
CYLD	Deubiquitinase	ND	DD1/DD2	Cell proliferation, ciliogenesis	[84]
Dysferlin	Skeletal muscle membrane repair, myogenesis, cell adhesion, intercellular calcium signaling	Domain C2	ND	Myogenesis	[107]
Mdp3	Stabilization factor of microtubules	Amino-terminal region	ND	Cell motility	[108]
Paxillin	Focal adhesion	Region rich in proline	ND	Polarization and cell migration	[84]
p62	Transport of misfolded proteins	Between the ZZ domain and the TRAF6 link area	DD2	Aggresome formation	[109]
RanBPM	Apoptosis, proliferation and cell migration		ND	Aggresome formation	[110]
Tau	Stabilization factor of microtubules	Tubulin binding region	SE14 domain	Aggresome formation	[109,111]
TPPP1	Polymerization and acetylation of microtubules		ND	Regulation of microtubule acetylation and β-catenin expression	[112]

DD: deacetylase domain; Mdp3: microtubule-associated protein (MAP) 7 domain-containing protein 3; ND: non determined; RanBPM: Ran-binding protein microtubule-organizing center; tau: tubulin-associated unit; TPPP1: tubulin polymerization-promoting protein-1.