Table 7.
Deregulation of HDAC6 expression in different types of cancers.
| Cancer Type | Cancers | Expression of HDAC6-Comments | References |
|---|---|---|---|
| Solid tumors | Bladder | Overexpressed | [113] |
| Melanoma | Overexpressed | [113] | |
| Lung | Overexpressed | [113] | |
| Oral squamous cell carcinoma | Overexpressed-Enhanced expression in advanced stages | [68,114] | |
| Ovarian carcinoma | Overexpressed-Enhanced expression in advanced stages | [68,114] | |
| Breast | Overexpressed-Prediction of a good or bad prognosis | [68,115] | |
| Hepatocytic carcinoma | Overexpressed-Enhanced expression in advanced stages | [68] | |
| Under-expressed-HDAC6 suggested as a tumor suppressor | [68,116] | ||
| Hematological | Chronic lymphocytic leukemia | Overexpressed-Observation on patient samples, cell lines and a transgenic mouse model | [114] |
| Acute myeloid leukemia | Overexpressed | [68,114] | |
| Acute lymphoblastic leukemia | Overexpressed-Enhanced expression in advanced stages | [68] | |
| Chronic lymphocytic leukemia | Overexpressed-Correlated with longer survival | [68] | |
| T-cell cutaneous lymphoma | Overexpressed-Correlated with longer survival | [68] | |
| Chronic myeloid leukemia | Overexpressed-Increased expression in CD34+ cells | [117] | |
| Multiple myeloma | Overexpressed | [118] | |
| Mantle cell lymphoma | Overexpressed | [118] | |
| Diffuse large B cell lymphoma | Overexpressed | [118] | |
| Peripheral T-cell lymphoma | Overexpressed | [118] |
CD: cluster of differentiation; HDAC6: histone deacetylase 6.