Figure 4.

Molecular target directly affecting the integrity of telomere. (A) G4-ligands bind with telomeric end to stabilize or promote the formation of G4 structure which abrogates the telomeric end extension. Telomerase inhibitors target either hTERT or hTR and block telomere extension, consequently disrupting telomere integrity. The CST complex is crucial for C-strand synthesis and defect in this complex dysregulate telomerase action and telomere loss. (B) Targeting components of the shelterin complex involved in the protection of telomeric end. (C) Use of T-oligos technology to block the lengthening of telomere. Figure is adapted and modified from the papers [192,206,207].