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. 2020 Feb 19;12(2):484. doi: 10.3390/cancers12020484

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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ChemRICH set enrichment statistics comparison for blood (a) and HCC tissues metabolites (b). (a) Significant chemical sets in blood metabolites for early HCC patients versus CLD subjects (blue) and comparing early-stage HCC versus late-stage HCC (orange). (b) Significant chemical sets in HCC tumor metabolites to paired non-malignant liver tissues for early HCC stages (red) and late HCC stages (black). The set enrichment significance level of p < 0.05 (−log p = 1.3) is indicated by red lines.