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. 2020 Feb 7;9(2):387. doi: 10.3390/cells9020387

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Occurrence of snoRNA/host gene alterations in the ten groups of cancers. (a) Percentage of copy number alterations (CNA) in snoRNA/host gene couples, across ten different tumor types (breast invasive carcinoma (BRCA), colorectal adenocarcinoma (COAD), glioblastoma multiforme (GBM), head and neck squamous cell carcinoma (HNSC), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), ovarian serous cystadenocarcinoma (OV), uterine corpus endometrial carcinoma (UCEC), skin cutaneous melanoma (SKCM), and kidney renal clear cell carcinoma (KIRC)) divided between couples never undergoing CNA (red), undergoing CNA in all tumors (blue), and undergoing CNA only in some tumor types (green). (b) Cumulative CNA frequency in the ten tumor types, calculated in each series as total number of CNA events divided for the total number of possible alterations (i.e., the number of snoRNA/host gene couples (295) times the number of patients in the series).