Table 2.
Relevance of snoRNA/host gene couples for which CNAs recur more frequently in multiple cancer types.
| snoRNA Host Gene |
Known Target |
Biological Relevance | Clinical Relevance |
References |
|---|---|---|---|---|
| SNORA63 EIF4A2 |
28S rRNA U4390 (Helix 89) -- |
Control of translation initiation, elongation and termination Translation initiation |
None reported Inversely correlates with prognosis in COAD, NSCLC, BRCA |
[49,50,51] |
| SNORA63E LINC00888 |
Unknown -- |
-- | None reported Increased in SKCM |
[52] |
| SNORD66 EIF4G1 |
18S rRNA C1272 (Helix 32) -- |
Translation initiation Translation initiation |
Biomarker of NSCLC in sputum, plasma and tissue; correlates to overall survival in NSCLC Inversely correlates with prognosis in BRCA, OV, NSCLC, PDA |
[53,54,55,56,57,58] |
| SNORA15 CCT6A |
18S rRNA U1367 (Helix 37) -- |
Activation of TGFbeta signaling |
None reported Correlates with negative prognosis in HCC |
[59,60] |
| SNORA14B TOMM20 |
18S rRNA U966 (Helix 23) -- |
E site/translation elongation Increases mitochondrial ATP synthesis |
None reported Overexpressed in various cancer types; potential therapeutic target in COAD |
[61,62] |
| SNORD72 RPL37 |
5.8S rRNA U55 (Helix 6) -- |
Formation of the ribosome small subunit Activator of ribosomal stress pathway |
None reported Overexpressed in PC |
[33,63,64] |
| SNORA56 DKC1 |
28S rRNA U1664 (Helix 37) -- |
Putative mRNA/tRNA binding rRNA pseudouridylation; regulates translational fidelity and Cap-independent translation; Telomere binding |
None reported Negatively correlates with survival in BRCA, and NSCLC |
[37,65,66,67,68] |
| SNORA36A DKC1 |
18S rRNA U105 (Helix 7) and U1244 (Helix 31) -- |
Binding of factors to form the 90S preribosome (H7); Translation elongation (H31) See above |
None reported See above |
[69,70] |
| SNORA70G RAP1B |
18S rRNA U1692 (Helix 28) -- |
Small ribosomal subunit maturation; translation initiation GTPase regulating cell adhesion, migration, polarity, differentiation, growth and angiogenesis |
None reported Negatively correlates with prognosis in GC; up-regulated in ESCC |
[71,72,73] |
COAD: colon adenocarcinoma; NSCLC: non-small cell lung carcinoma; BRCA: breast cancer; SKCM: skin cutaneous melanoma; OV: ovarian cancer; PDA: pancreatic ductal adenocarcinoma; HCC: hepatocellular carcinoma; PC: prostate cancer; GC: gastric cancer; ESCC: esophageal squamous cell carcinoma.