Table 1.
Overview of viral miRNA regulatory functions and targets.
| VIRUS | miRNA | Targets | Effects of miRNAs |
|---|---|---|---|
| EBV | ebv-BHRF1-2 | IL-12, CATHEPSIN B, AEP, GILT | Immune evasion |
| ebv-BHRF1-3 | BHRF1-3, TAP | ||
| ebv-BART1-5p | IL12, CATHEPSIN B, AEP, GILT | ||
| ebv-BART2-5p | MICB, IL-12, CATHEPSIN B, AEP, GILT | ||
| ebv-BART3-3p | IPO7 | ||
| ebv-BART5-5p | LMP1 | ||
| ebv-BART6-3p | RIG-1 | ||
| ebv-BART15 | NLRP3 | ||
| ebv-BART16 | CREB-BP | ||
| ebv-BART17-5p | TAP | ||
| ebv-BART22 | LMP2A | ||
| ebv-BHRF1-1 | P53 | Anti-apoptosis | |
| ebv-BHRF1-2 | PRDM1/Blimp1 | ||
| ebv-BHRF1-3 | PTEN | ||
| ebv-BART1-3p | CASP3 | ||
| ebv-BART4-5p | Bid | ||
| ebv-BART5-5p | PUMA | ||
| ebv-BART6-5p | OCT1 | ||
| ebv-BART8 | STAT1 | ||
| ebv-BART13-3p | CAPRIN2 | ||
| ebv-BART16 | CREB-BP, TOMM22, CASP3, SH2B3 | ||
| ebv-BART22 | MAP3K5, CASP3, PAK2, TP53INP1 | ||
| ebv-BART22 | NDRG1 | Promote metastasis | |
| ebv-BHRF1-1 | RNF4 | Promote viral production | |
| ebv-BHRF1-2 | BHRF1 | Maintain latency | |
| ebv-BART2-5p | BALF5 | ||
| ebv-BART6-5p | DICER | ||
| ebv-BART18-5p | MAP3K2 | ||
| ebv-BART20-5p | BZLF1, BRLF1 | ||
| ebv-BART1-5p | LMP1 | Promote cancer development | |
| ebv-BART16 | LMP1 | ||
| ebv-BART17-5p | LMP1 | ||
| ebv-BART1-5p | PTEN | Promote tumor metastasis | |
| ebv-BART7-3p | PTEN | ||
| ebv-BART9 | E-Cadherin | ||
| ebv-BART10-3p | BTRC | ||
| ebv-BART6-3p | PTEN | Promote proliferation | |
| ebv-BART11 | FOXP1 | ||
| KSHV | kshv-miR-K12-1 | Casp3 | Apoptosis |
| kshv-miR-K12-3 | Casp3 | ||
| kshv-miR-K12-4 | Casp4 | ||
| kshv-miR-K12-5 | Tmskα1 | ||
| kshv-miR-K12-10a | TWEAK | ||
| kshv-miR-K12-12 | CASP3, CASP7 | ||
| kshv-miR-K12-1 | NF-κB signaling/IκBα | KSHV latency | |
| kshv-miR-K12-3 | nuclear factor I/B, GRK2 | ||
| kshv-miR-K12-4 | Rbl2 | ||
| kshv-miR-K12-7 | RTA (KSHV ORF50) | ||
| kshv-miR-K12-9 | RTA (KSHV ORF50), BCLAF1 | ||
| kshv-miR-K12-10a | BCLAF1 | ||
| kshv-miR-K12-11 | MYB, IKKε | ||
| kshv-miR-K12-1 | THBS1 | Cell adhesion, migration, and angiogenesis | |
| kshv-miR-K12-3 | THBS1 | ||
| kshv-miR-K12-6 | THBS1, Bcr, SH3BGR | ||
| kshv-miR-K12-11 | THBS1 | ||
| kshv-miR-K12-1 | CASTOR1, STAT3,p21 | Promote tumorigenesis, Cell survival | |
| kshv-miR-K12-4 | CASTOR1 | ||
| kshv-miR-K12-10a | TGFBR2 | ||
| kshv-miR-K12-10b | TGFBR2 | ||
| kshv-miR-K12-11 | SMAD5 | ||
| kshv-miR-K12-1 | MICB | Immune evasion | |
| kshv-miR-K12-3 | C/EBPβ p20 (LIP) | ||
| kshv-miR-K12-5 | MYD88 | ||
| kshv-miR-K12-7 | C/EBPβ p20 (LIP), MICB | ||
| kshv-miR-K12-9 | IRAK1 | ||
| kshv-miR-K12-11 | C/EBPβ | ||
| kshv-miR-K12-1 | MAF | Differentiation of infected cells | |
| kshv-miR-K12-6 | MAF | ||
| kshv-miR-K12-11 | MAF/BACH-1 | ||
| HPV | HPV16-miR-H1 | BCL11A, CHD7, ITGAM, RAG1, TCEA1 | Immune evasion |
| HPV16-miR-H2 | SP3, XRCC4, JAK2, PKNOX1, FOXP1 | ||
| HBV | HBV-mir-2 | TRIM35 | Promote tumorigenesis |
| HBV-mir-3 | HBsAg, HBeAg, HBc | Self-replication | |
| MCPyV | MCV-miR-M1-5p | SP100 | Immune evasion |
| MCV-miR-M1 | RUNX1 | Viral proliferation |