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. 2020 Jan 21;12(2):259. doi: 10.3390/cancers12020259

Figure 1.

Figure 1

Evolutionary conservation of Rab GTPase proteins. (a) The surface representation of Rab1a crystal structure (green) from Homo sapiens (PDB ID: 4FML) shows residues that are fully conserved across all human Rab proteins (PDB IDs: 3TKL, 6IF2, 5LPM, 2IL1, 1X3S, 1Z0F, 2A5J, 2P5S, 6HUF, 1YZT, 2FG5, 1Z22, 4QXA, 2F7S, 20CB, 3TS0); (b) Residues that are 100% conserved across Rab1a proteins from multiple species (mouse, rat, wolf, human, pig, thale cress, slime mold, great pond snail) are shown in blue.