Table 3.

Summary of studies reporting circulating miRNA expression findings in adrenocortical cancer.

Author and Year of Publication	Reference	Source	Method	Samples	miRNA Overexpressed in ACC	miRNA Underexpressed in ACC
Chabre et al. (2013)	[24]	Serum	qRT-PCR	23 ACC, 4 ACA, 19 NA	miR-483-5p	miR-195, miR-335
Patel et al. (2013)	[69]	Serum	qRT-PCR	17 ACC, 22 ACA	miR-34a, miR-483-5p
Szabó et al. (2014)	[70]	Plasma	qRT-PCR	13 ACC, 12 ACA	miR-100, miR-181b, miR-184, miR-210, miR-483-5p
Perge et al. (2017)	[72]	Plasma-extracellular vesicle	qRT-PCR	22 ACC, 24 ACA	miR-101, miR-483-5p
Salvianti et al. (2017)	[71]	Plasma	qRT-PCR	27ACC, 13ACA, 10 NA	miR-483-5p
Perge et al. (2018)	[73]	Plasma-extracellular vesicle	qRT-PCR	9 CP-ACC, 13 CPA, 13 NFA	miR-22-3p, miR-27a-3p, miR-320b, miR-210-3p
Decmann et al. (2019)	[74]	Plasma	qRT-PCR	23 ACC, 23 ACA	miR-483-5p
Decmann et al. (2018)	[51]	Plasma	qRT-PCR	11 ACC, 11 ACA, 11 AML	miR-483-3p, miR-483-5p

Abbreviations: ACC: adrenocortical cancer, ACA: adrenocortical adenoma, AML: adrenal myelolipoma, CP-ACC: cortisol-producing ACC, NA: normal adrenal.