Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 21;9(2):266. doi: 10.3390/cells9020266

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Schematic representation of mechanisms of action of specific Pol I transcription inhibitors. (A) Mode of action of CX-3543, disruption of Nucleolin binding to G4 DNA structures. (B) Mode of action of CX-5461, disruption of Pol I-SL-1 interaction and an unclear role in G4 stabilization. (C) Mode of action of BMH-21, disruption of Pol I complex and ubiquitin-mediated proteasome degradation of POLR1A (RPS194), inhibition of transcription elongation and an unclear role in G4 stabilization.