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. 2020 Jan 25;10(2):188. doi: 10.3390/biom10020188

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of GAL-021 on BK_Ca-channel activity in α-hSlo-expressing HEK293T cells. Cells were suspended in high-K⁺ solution containing 0.1 μM Ca²⁺, and inside-out current recordings were made at the holding potential of +60 mV. (A) Representative BK_Ca-channel currents obtained in the control (left) and after bath application of 30 μM GAL-021 (right). (B) Summary bar graph depicting effect of GAL-021 (10 or 30 μM) and GAL-021 (30 μM) plus BMS-191011 (10 μM) on the open-state probability of BK_Ca (or KCNMA1) channels (mean ± SEM and n = 6 to 8 for each bar). ^*, Significantly different from control or GAL-021 (10 μM) alone group (p < 0.05); ^**, significantly different from control (p < 0.01); and ^†, significantly different from GAL-021 (30 μM) alone group (p < 0.05).