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. 2020 Feb 1;10(2):212. doi: 10.3390/biom10020212

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Maraviroc induced an almost complete CCR5 blockade in maraviroc CFC-trained rats as compared to vehicle-treated animals (n = 5 rats/group, p < 0.05). Vehicle-treated rats are expressed as 100% of band signal (densitometry). All data are expressed as percentage control (vehicle percentage). CCR5 is upregulated by fear memory (12 and 24 h after CFC session) and maraviroc prevented these upregulations (see Western blot (41 Kda band for CCR5) and quantification). Bands for CCR5 were normalized with beta actine. Mara: Maraviroc CFC-treated rats (100 mg/Kg, i.m); Vehicle: Rats received vehicle and these animals were trained in a CFC paradigm (1 mA); CFC12h: Fear memory consolidation at 12 h after CFC session; CFC24h: Fear memory consolidation at 24 h after CFC session.