Figure 1.

Schematic representation of the discovery timeline of marine-derived drugs approved for cancer treatment. It shows their chemical structures, images of the marine organism where these drugs were first originated and the major biological effects of the drugs on cancer cells. The images for Cytarabine, Fludarabin, Nelarabine, and Eribulin are adapted from http://spongeguide.org. The images for Trabectedin and Brentuximab vedotin are adapted from http://bioweb.uwlax.edu and http://seaslugs.free.fr, respectively. The images for Plitidepsin and Polazutumab vetodin are from PharmaMar.