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. 2020 Jan 28;9(2):315. doi: 10.3390/cells9020315

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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6-OHDA PD model phenotypic validation. Using the apomorphine turning behavioral test, it was verified that after 3 weeks of 6-OHDA injections, there was (A) an intense turning behavior promoted by the injection of apomorphine when compared to Sham group, demonstrating that animals’ dopaminergic integrity was affected. Additionally, through the staircase test, it was verified that after 6-OHDA administration there was a (B,C) significant reduction on fine motor coordination of the tested animals. For apomorphine turning behavioral test Sham n = 9, 6-OHDA n = 18. For staircase Sham n = 9, 6-OHDA n = 18. Data presented as mean ± S.E.M. *** p < 0.001. FCR—forced choice task at right side; FCL—forced choice task at left side.