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. 2020 Jan 28;9(2):315. doi: 10.3390/cells9020315

Figure 3.

Figure 3

Impact of hBM-MSCs secretome and levodopa interventions on motor coordination performance of 6-OHDA PD animals—staircase. (A) The paw reaching motor coordination performance of the animals demonstrated a significant amelioration (at one week, p < 0.05) of the forelimb coordination of the hBM-MSCs secretome-injected animals when compared to the untreated group 6-OHDA. Even under a (B,C) paw reaching forced-task, the animals injected with hBM-MSCs secretome presented a better performance (at one week after injection; p < 0.05) when compared to the untreated group 6-OHDA on the (B) (left) affected side (FCL). Such pieces of evidence, were, in turn, not observed in the levodopa-treated animals when compared to the untreated group 6-OHDA (A–C). Sham n = 9, 6-OHDA n = 7, Levodopa n = 5, and hBM-MSCs secretome n = 6. Data presented as mean ± S.E.M. *hBM-MSCs secretome-injected animals statistically different from 6-OHDA, p < 0.05; #Sham animals statistically different from 6-OHDA, hBM-MSCs secretoma and levodopa-injected animals, *** p < 0.001. FCR—forced choice task at right side; FCL—forced choice task at left side.