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. 2020 Feb 17;12(2):464. doi: 10.3390/cancers12020464

Figure 4.

Figure 4

miR-125b-5p is delivered into M1 macrophages by melanoma-derived exosomes. (A) qRT-PCR for miR-125b-5p in THP-1-derived M1 macrophages with and without 48 h treatment with exosomes derived from different melanoma cell lines (* p ≤ 0.05; *** p ≤ 0.001; ns: not significant). qRT-PCR analysis of primary and mature transcripts of miR-125b after (B) co-culture (48 h) of THP-1- derived M1 macrophages with NHEM or MV3 melanoma cell line or (C) treated (48 h) with and without MV3-derived exosomes. Bars represent the average ± standard deviation of at least three independent experiments (* p ≤ 0.05).