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. 2020 Jan 25;10(2):185. doi: 10.3390/biom10020185

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Histopathological analysis of ear biopsy from TPA-induced psoriasis-like mice model: Section of ear tissue samples were stained with H&E, (A) Negative control displays normal skin similar to vehicle control (B) with normal epidermis (Ep), dermis (De), sebaceous gland (Sg), cartilage (CT). In ear tissue of (C) TPA-induced psoriasis, prominent changes were observed with the presence of hyperkeratosis (Hk) and hyperplastic epidermis (Ep), inflammatory cells (In), with rete ridge (Rr) and pustule (Pu) formation. Decrease in both number and severity of these hallmarks were observed with 410 mg/kg + 20 μL T.A. (E) and 1230 mg/kg + 20 μL T.A. (F) of WSSO treatments. Dexamethasone (D) also significantly reduced psoriasis-like symptoms. Higher magnification images (inset) are displayed, scale bar represents 100 and 20 μm for low and high magnification images.