. 2020 Jan 25;9(2):291. doi: 10.3390/cells9020291

Table 3.

Association analysis between immune cell infiltration and clinic-pathological data. tNLR, tissue NLR; CIS, carcinoma in situ; p value estimated by # Kruskal-Wallis test or * Mann-Whitney test.

Clinicopathological Variables		CD66b⁺ TAN Density		CD3⁺ T Cells Density		tNLR (CD66b⁺/CD3⁺)
Clinicopathological Variables	N° (%)	Median	p	Median	p	Median	p
Total	84 (100)	78		396
Gender			0.76 *		0.47 *		0.90 *
Female	16 (19)	51		328		0.186
Male	68 (81)	86		399		0.216
Age			0.80 *		0.26 *		0.55 *
< median	39 (46)	83		327		0.186
≥ median	45 (54)	73		415		0.224
pT category			0.11 *		0.003 *		0.35 *
pT2	25 (30)	106		544		0.136
pT3-pT4	59 (70)	60		304		0.292
pN category			0.10 *		0.19 *		0.50 *
pN+	27 (32)	106		403		0.154
pN0	57 (68)	48		357		0.234
Overall Stage			0.14 *		0.001 *		0.32 *
II	22 (26)	123		587		0.149
III-IV	62 (74)	56		312		0.263
CIS			0.46 *		0.65 *		0.90 *
No	34 (40)	107		381		0.183
Yes	50 (60)	68		402		0.239
pSTAT3			0.048 *		0.43 *		0.28 *
Low	43 (51)	51		357		0.176
High	41 (49)	126		400		0.243
Subtype			0.007#		0.75 ^#		0.06 ^#
Luminal	41 (49)	51		401		0.136
Basal	20 (24)	178		398		0.359
Non-Type	23 (27)	60		366		0.304
FOSL1			0.054 *		0.227 *		0.55 *
Low	19 (22)	58		418		0.291
High	22 (26)	155		398		0.281