Figure 7.

Analysis of all GeneLab datasets utilized for direct comparisons with the GSEA C6 oncology signature collection analysis. (A) Auto-annotated C6 GSEA terms from Cytoscape’s enrichment mapper. Each node represents one specific C6 term with each wedge representing one GeneLab dataset utilized for this manuscript. The yellow circles represent the auto-annotated GO terms with common related pathways. (B) Heatmap with k-means clustering for the specific C6 pathways. Five specific pathways were found to be clustered together through k-means clustering. (C) Scatter plots comparing the normalized enrichment scores (NES) to dose in milligrays and fits with a generalized additive model (GAM) on each cluster (represented in (B)). Each panel represents one of the clusters and the color-coded lines represent GAM fits performed on each C6-annotated term in the cluster. The circles in the plots represent the gene sets and the pink shade around the GAM fits represent the standard error.