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. 2020 Feb 3;12(2):334. doi: 10.3390/cancers12020334

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The nuclei were larger in olaparib-resistant cells than in parental cells. The degree of DNA condensation was examined by 4′,6-diamidino-2-phenylindole (DAPI) staining and confocal laser microscopy. Representative images are presented (80× original magnification). Scale bars represent 50 μm. In olaparib-resistant cells, increased nucleus indicates a relaxation of DNA condensation (A). The proportion of cells with a DNA content of more than 4n was calculated by flow cytometry with PI staining. The increased nuclear size of olaparib-resistant cells was not related to aneuploidy (B).

The nuclei were larger in olaparib-resistant cells than in parental cells. The degree of DNA condensation was examined by 4′,6-diamidino-2-phenylindole (DAPI) staining and confocal laser microscopy. Representative images are presented (80× original magnification). Scale bars represent 50 μm. In olaparib-resistant cells, increased nucleus indicates a relaxation of DNA condensation (A). The proportion of cells with a DNA content of more than 4n was calculated by flow cytometry with PI staining. The increased nuclear size of olaparib-resistant cells was not related to aneuploidy (B).