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Topoisomerase 1 (TOP1) activity was increased and tyrosyl-DNA phosphodiesterase 1 (TDP1) expression was downregulated in olaparib-resistant cells. TOP1 activity was increased in all olaparib-resistant cells compared with parental cells (A), although the protein expression of TOP1 was not altered (B). TDP1 protein expression was downregulated in olaparib-resistant SNU-484, SNU-668, and KATO-III cells compared with their parental cells (B). * indicates p < 0.001.
