Table 1.
Drug sensitivity in parental and olaparib-resistant cells, as assessed by using cell growth-inhibition assay.
| Cell Lines * | Olaparib IC50 (μmol/L, mean ± SD) | Cisplatin IC50 (μmol/L, mean ± SD) | Paclitaxel IC50 (μmol/L, mean ± SD) | Irinotecan IC50 (μmol/L, mean ± SD) | |
|---|---|---|---|---|---|
| SNU-484 | Parental cells | 4.16 ± 0.05 | 0.8 ± 0.01 | 2.7 ± 0.3 | 3.96 ± 0.2 |
| Olaparib-resistant cells | >10 | 2.02 ± 0.03 | 2.5 ± 0.08 | 1.47 ± 0.2 | |
| SNU-601 | Parental cells | 0.73 ± 0.006 | 0.75 ± 0.005 | 4.63 ± 0.08 | 1.053 ± 0.03 |
| Olaparib-resistant cells | 7.3 ± 0.4 | 3.92 ± 0.05 | 4.92 ± 0.05 | 1.82 ± 0.007 | |
| SNU-668 | Parental cells | 11.07 | 5.88 ± 0.2 | 5.35 ± 0.1 | >10 |
| Olaparib-resistant cells | >20 | >10 | 5.66 ± 0.1 | 5.95 ± 0.1 | |
| KATO-III | Parental cells | 3.56 ± 0.4 | >10 | 5.67 ± 0.1 | >10 |
| Olaparib-resistant cells | >10 | 4.13 ± 0.4 | 5.82 ± 0.1 | 5.5 ± 0.4 | |
* MTT for 5 days.