Table 2.
Number of pathogenic variant carriers with breast cancer <36 years after left censoring at date of PV report.
| Genetic Variant | Total Breast Cancers (n) | Contralateral Breast Cancers (n) | Synchronous Breast Cancers (n) | Years of Follow-Up | Annual Rate Contralateral Breast Cancer (Excluding Synchronous) (%) | Annual Rate All Contralateral and Synchronous Breast Cancers |
|---|---|---|---|---|---|---|
| BRCA1 | 108 | 7 (6.5) | 0 (0.0) | 280 | 2.50 | 2.50 |
| BRCA2 | 63 | 3 (4.8) | 1 (1.6) | 187.0 | 1.07 | 1.60 |
| TP53 | 19 | 5 (26.3) | 1 (5.3) | 37.6 | 10.65 | 13.31 |
| Total | 190 | 15 (7.9) | 2 (1.1) | 504.4 | 2.58 | 2.97 |