Table 2.

Features associated with mortality through a univariate and multivariate Cox proportional hazards analysis.

Characteristic	Univariate Analysis		Multivariate Analysis
	HR (95% CI)	p-value	HR (95% CI)	p-value
HCV-induced HCC	2.43 (1.43–4.13)	0.001	2.17 (1.21–3.87)	0.009
NASH-induced HCC	0.23 (0.05–0.94)	0.04	0.74 (0.16–3.43)	0.70
BCLC stage
-A
-B	2.74 (1.40–5.34)	0.003	2.82 (1.37–5.81)	0.005
-C	2.93 (1.42–6.06)	0.004	2.72 (1.22–6.05)	0.01
Previous treatment	2.33 (1.41–3.85)	0.001	1.66 (0.96–2.86)	0.07
Markers of portal hypertension a	2.07 (1.24–3.45)	0.005	1.37 (0.79–2.38)	0.26
High visceral adipose Radiodensity (VAT HU≥ −85 HU)	2.56 (1.54–4.26)	0.002	2.01 (1.14–3.54)	0.02

BCLC, Barcelona-Clinic Liver Cancer; CI, confidence interval, HCV, hepatitis C; HR, hazard Ratio; NASH, non-alcoholic steatohepatitis. ^a Markers of portal hypertension includes splenomegaly, esophageal varices or thrombocytopenia (platelet count <100,000/mm³). HRs and P values were estimated using Cox proportional hazard model.