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. 2020 Feb 18;12(2):466. doi: 10.3390/cancers12020466

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of venetoclax on the intracellular accumulation of mitoxantrone[³H] in parental and ABCG2-overexpressing cells. (A) Effect of venetoclax on mitoxantrone[³H] accumulation in HEK293/pcDNA3.1, HEK293/ABCG2-R482, HEK293/ABCG2-R482G and HEK293/ABCG2-R482T cells. (B) Effect of venetoclax on mitoxantrone[³H] accumulation in NCI-H460 and NCI-H460/MX20 cells. (C) Effect of venetoclax on mitoxantrone[³H] accumulation in S1 and S1-M1-80 cells. Columns with error bars represent mean ± SD from 3 independent duplicate experiments. Asterisks (*) indicate p < 0.05 versus control group (untreated resistant cells).

Effect of venetoclax on the intracellular accumulation of mitoxantrone[³H] in parental and ABCG2-overexpressing cells. (A) Effect of venetoclax on mitoxantrone[³H] accumulation in HEK293/pcDNA3.1, HEK293/ABCG2-R482, HEK293/ABCG2-R482G and HEK293/ABCG2-R482T cells. (B) Effect of venetoclax on mitoxantrone[³H] accumulation in NCI-H460 and NCI-H460/MX20 cells. (C) Effect of venetoclax on mitoxantrone[³H] accumulation in S1 and S1-M1-80 cells. Columns with error bars represent mean ± SD from 3 independent duplicate experiments. Asterisks (*) indicate p < 0.05 versus control group (untreated resistant cells).