Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 18;12(2):466. doi: 10.3390/cancers12020466

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Effect of venetoclax on the efflux of mitoxantrone[³H] in parental and ABCG2-overexpressing cells. Time course (0/30/60/120 min) versus the percentage of remaining intracellular mitoxantrone[³H] was plotted to illustrate the effect of venetoclax on mitoxantrone[³H] efflux in (A) HEK293/pcDNA3.1, (B) HEK293/ABCG2-R482, (C) HEK293/ABCG2-R482G, (D) HEK293/ABCG2-R482T, (E) NCI-H460, (F) NCI-H460/MX20, (G) S1 and (H) S1-M1-80 cells. Points with error bars represent mean ± SD from 3 independent duplicate experiments. Asterisks (*) indicate p < 0.05 versus control group (untreated resistant cells).

Effect of venetoclax on the efflux of mitoxantrone[³H] in parental and ABCG2-overexpressing cells. Time course (0/30/60/120 min) versus the percentage of remaining intracellular mitoxantrone[³H] was plotted to illustrate the effect of venetoclax on mitoxantrone[³H] efflux in (A) HEK293/pcDNA3.1, (B) HEK293/ABCG2-R482, (C) HEK293/ABCG2-R482G, (D) HEK293/ABCG2-R482T, (E) NCI-H460, (F) NCI-H460/MX20, (G) S1 and (H) S1-M1-80 cells. Points with error bars represent mean ± SD from 3 independent duplicate experiments. Asterisks (*) indicate p < 0.05 versus control group (untreated resistant cells).