Table 2.
Overview of radioembolization (RE)-induced hypertrophy.
| Author | RE Mod | RE Dose/Activity † | Mean F/U Period Following RE |
KGR/Week in % | FLR/TLV at Baseline in % | FLR/TLV After 90Y in % | Mean Degree of Relative Hypertrophy Level in % |
|---|---|---|---|---|---|---|---|
| Edeline [21] | G+R | 122 Gy, 2.5 GBq | 3 mo | 1.1 | 42.3 | 55.5 | + 29 |
| Fernandez-Ros [22] | R | - | 4–8 wks 10–26 wks >26 wks |
0.8 - - |
29.0 § - - |
32 § 40 § 50 § |
+ 12.6 + 23.0 + 39.3 |
| Gaba [15] | G | 132 Gy 2.2 GBq |
18 mo | 1.9 | 42.9 | 68.6 | + 40.0 |
| Gabr [34] | G | 140 Gy | 2.9 mo | 2.5 * | 35.0 * | 45.0 * | + 23.3 (unilobar) + 9 (segmental) |
| Garlipp [23] | R | 1.2 GBq | 46 days † | 0.7 | 23.4 § | 27.9 § | + 29; + 25.3 † |
| Goebel [24] | G | 113 Gy § 2.9 GBq § |
1 mo 3 mo 6 mo 9 mo (n = 61) |
0.9 0.8 0.7 0.5 |
33.9 - - - |
37.6 44.2 50.9 53.1 |
+ 16.9 + 29.3 + 40.9 + 43.4 |
| Jakobs [14] | G | 120 Gy | 4 wks | 0.6 * | 31.2 * | 44.4 * | + 21.2; + 8.7 † |
| Justinger [25] | R | 1.3 GBq | 8 wks | 1.3 | 30.4 § | 40.4 § | - |
| Lewandowski [26] | G | 154 Gy | 40 days † | 1.7 | 33.0 | 43.9 | + 30 |
| Orcutt [27] | G | 132 Gy | 1 mo; 1.1 mo † 3 mo; 3.8 mo † 6 mo; 6.3 mo † |
0.8 0.5 0.4 |
33.0 - - |
37.5 41.9 44.5 |
+ 16.7; + 11 † + 31.1; + 17.4 † + 38.5; + 31.3 † |
| Palard [28] | G | - | 5.9 | 0.7 | 49.6 § | 66.9 § | + 35.4 |
| Rayar [29] | G | 2 GBq | 7.6 mo † | 0.3 | 27.2 | 35.9 | + 8.7 |
| Teo [30] | R | - | 5.7 mo † | 0.5 | 32.7 § | 45.5 § | + 34.2 |
| Teo [31] | R | 4–6 wks 8–12 wks (n = 22) |
0.3 - |
31.7 § - |
33.8 § 39.7 § |
+ 5.6; + 3 † + 21.2; + 9 † |
|
| Theysohn [32] | G | - | 1 mo 3 mo 6 mo 9 mo 12 mo |
0.7 0.8 0.6 0.5 0.4 |
35.0 § - - - - |
37.7 45.4 50.4 § 54.0 56.5 |
+ 7.1 + 22.9 + 30.8 + 35.7 + 40.1 |
| Vouche [33] | G | 112 Gy | 1 mo (n = 80) 45 days to 3 mo (n = 34) 3-6 mo (n = 42) 6-9 mo (n = 28) >9 mo (n = 25) |
0.6 - - - - |
24.4 - - - - |
27.0 27.8 34.7 34.3 36.4 |
+ 7 † + 24 † + 35 † + 36 † + 45 † |
RE: radioembolization, mod: modality, F/U: follow-up, KGR: kinetic growth rate, FLR: future liver remnant, TLV: total liver volume, 90Y: treatment with yttrium, G: glass microspheres, R: resin microspheres, mo: months, wks: weeks, -: data not available. † values are median, § values are mean, * only patients with unilobar treatment were considered.