Table 1.

Summary of the studies of mitophagy in acute kidney injury (AKI).

AKI Categories	Pathways that Regulate Mitophagy	Roles on AKI	Mechanisms	References
Renal Ischemia- Reperfusion	P53/sestrin-2 pathway, HIF-1α/BNIP3 pathway	Protect against AKI	Modulate cell apoptosis	[107]
	DRP1-dependent pathway	Protect against AKI	Eliminate damaged mitochondria	[94]
	PINK1/PARK2 pathway	Protect against AKI	1. Eliminate damaged mitochondria	[45,108]
			2. Modulate the removal of ROS
			3. Relieve inflammatory response
			4. Suppress mitochondrial depolarization
			5. Improve ATP production
	BNIP3-mediated pathway	Protect against AKI	1. Remove damaged mitochondria	[109]
			2. Modulate the elimination of ROS
			3. Relieve inflammatory response
	OPA1-related pathway	Protect against AKI	1. Degrade the damaged mitochondria	[110]
			2. Interrupt the mitochondrial damage signalling
Cisplatin-induced AKI	PINK1/PARK2 pathway	Protect against AKI	1. Suppress apoptosis	[111,112,113]
			2. Protect mitochondrial function
			3. Inhibit Drp1-mediated mitochondrial fission
	DRP1-dependent pathway	Protect against AKI	Inhibit mitochondrial dysfunction	[93]
	HIF-1α/BNIP3/BCEN-1 pathway	Protect against AKI	Alleviate apoptosis	[114]
Spesis-induced AKI	PINK1/PARK2 pathway	Protect against AKI	Prevent cell apoptosis	[115]
Contrast media-Induced AKI	PINK1/PARK2 pathway	Protect against AKI	1. Reduce mitochondrial ROS	[35,116]
			2. Inhibit NLRP3 inflammasome activation