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. 2020 Feb 21;12(2):500. doi: 10.3390/cancers12020500

Figure 3.

Figure 3

PTP1B mediates IL-13-triggered cell adhesion, migration, invasion and proliferation in cancer cells. U87MG, KM12SM, and A2780 cells were transfected with control or PTP1B siRNA #1. (A) PTP1B silencing was verified 48 h after transfection by Western blot. (B) Colorectal cancer transfectants were subjected to cell adhesion. (C) Glioblastoma and colorectal cancer transfectants were subjected to MTT. Then, the three cancer transfectants were subjected to (D) migration and (E) invasion assays. All assays were done in the presence or absence of IL-13. Cell adhesion/migration/invasion/optical density was significantly increased by addition of IL-13 (** p < 0.01; *** p < 0.001) and declined after PTP1B silencing (◊◊ p < 0.01; ◊◊◊ p < 0.001).