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. 2020 Feb 21;12(2):500. doi: 10.3390/cancers12020500

Figure 7.

Figure 7

PTP1B inhibition increases survival in CRC and glioblastoma mouse models. (A) RT-PCR assays of RNA isolated from livers to detect human GAPDH as a surrogate of liver colonization by KM12SM cells previously transfected with the indicated siRNAs. Murine β-actin amplification was used as a loading control. (B) Kaplan–Meier survival analysis for mice inoculated intrasplenically with metastatic KM12SM cells and treated with Claramine. Treatment significantly increased mice survival (*** p < 0.001). (C) Mice were subcutaneously inoculated with U251 cells and treated with PBS or Claramine after 15 days of implantation. Claramine significantly inhibited tumor growth (* p< 0.05; *** p < 0.001). (D) Mouse weight during the treatment with Claramine remained constant. (E) Kaplan–Meier survival analysis for mice inoculated intracranially with GBM12 PDX cells. Treatment with Claramine started 7 days after tumor implantation and significantly increased mice survival (*** p < 0.001).