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The effect of low molecular weight heparins (LMWHs) on heparan sulfate proteoglycans/heparanase. LMWHs antagonize the activity of heparanase through increased tissue factor pathway inhibitor (TFPI) release and the inhibition of vascular endothelial growth factor A (VEGF-A) and fibroblast growth factor 2 (FGF-2). They also inhibit the degradation of extracellular matrix (ECM), resulting in reducing desmoplasia in the TME.
