17β-HSD |
17β-hydroxysteroid-dehydrogenase |
3β-HSD |
3β-hydroxysteroid-dehydrogenase |
AD |
4-androstene-3,17-dione |
CYP |
cytochrome P450 |
DHEA |
dehydroepiandrosterone |
DHEA-S |
dehydroepiandrosterone-3-sulfate |
DMEM/F-12 |
Dulbecco’s modified Eagle medium F-12 |
DPBS |
Dulbecco’s phosphate buffered saline |
E1 |
estrone |
E1-S |
estrone-3-sulfate |
E2 |
17β-estradiol |
E2-G |
17β-estradiol-3-O-(β-d-glucuronide) |
E2-S |
17β-estradiol-3-sulfate |
E3 |
estriol |
EOC |
epithelial ovarian cancer |
ERα |
estrogen receptor alpha |
ESR1
|
estrogen receptor alpha gene |
ESR2
|
estrogen receptor beta gene |
ESRRG
|
estrogen-related receptor gamma gene |
FBS |
fetal bovine serum |
HGSOC |
high grade serous ovarian cancer |
IL-6 |
interleukin-6 |
IL-6R |
interleukin-6 receptor |
Km
|
Michaelis constant |
LC-HRMS |
liquid chromatography high-resolution mass spectrometry |
LLOQ |
lower limit of quantification |
PARP |
poly(ADP-ribose)-polymerase 1 |
PXR |
pregnane X receptor |
STR |
short tandem repeats |
SULT |
sulfotransferase |
T |
testosterone |
TCZ |
tocilizumab |
UGT |
uridine 5’-diphospho-glucuronosyltransferase |
VEGF |
vascular endothelial growth factor |
Vmax
|
maximum reaction velocity |