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. 2020 Feb 19;12(2):479. doi: 10.3390/cancers12020479

Figure 1.

Figure 1

Tripartite motif-containing protein 72 (TRIM72) adenosine diphosphate (ADP)-ribosylation cycle in membrane repair. Ischemia-reperfusion-induced membrane disruption increased the ADP-ribosylation of TRIM72 by ADP-ribosyltransferase (ART) 1 at the sites of membrane damage, facilitating binding of TRIM72 and caveolin-3 to the membrane. Oligomerization of TRIM72 is essential for acute membrane repair and involves the recruitment of TRIM72 and intracellular vesicles at the injury sites [78]. ADP-ribosylarginine hydrolase (ARH) 1 catalyzes de-ADP-ribosylation of modified TRIM72, cleaving the ADP-ribose from ADP-ribosylated (arginine)TRIM72, promoting oligomerization of TRIM72 at the sites of injury.