Table 2.
Characterization of ADP-ribosylation by ADP-ribosyltransferase (ART)1 of mouse heart and skeletal muscle proteins. Art1-deficient mouse heart and skeletal muscle contained very few proteins ADP-ribosylated on arginine residues compared to the wild-type, which suggested that ART1 is a major contributor to ADP-ribosylation in skeletal muscle and heart. Data derived from Figure 3B from Leutert et al. [39].
| Number of ADP-Ribosylated Protein | ADP-Ribosylated Amino Acid | ||||||
|---|---|---|---|---|---|---|---|
| Arg | Glu | Lys | Ser | Asp | Met | ||
| C2C12 cells | Wild-type | 33 | 0 | 1 | 1 | 1 | 0 |
| Skeletal muscle | Wild-type | 303 | 0 | 2 | 1 | 1 | 0 |
| Art1-KO | 6 | 2 | 2 | 4 | 1 | 0 | |
| Heart | Wild-type | 60 | 5 | 5 | 7 | 2 | 1 |
| Art1-KO | 0 | 4 | 4 | 7 | 2 | 0 | |