Table 1.
Overview of reviewed Clinical Decision Support Systems *.
| CDSS | Users | Sample | Clinical Question | Clinical & Pathological Input | Method | Access | URL |
|---|---|---|---|---|---|---|---|
| Adjuvant! Online [27] | HC | 631 | Risk of recurrence and death at 10 years; Estimated benefits of adjuvant endocrine and chemotherapy | Surveillance, epidemiology, SEER, and efficacy of adjuvant therapy | Kaplan Meier analysis | Not available | www.adjuvantonline.com |
| PREDICT [28,29] | HC/P | 5694 | Prediction of survival at 5, 10 and 15 years with different treatment options | Age, tumour size and grade, PN, ER, HER2, Ki67 and mode of detection | Cox regression models | Online | https://breast.predict.nhs.uk/ |
| ONCOassist [30] | HC | 5694 | What is the most appropriate treatment following breast cancer surgery? Prediction of survival at 5, 10 and 15 years | Patient age, tumour size, tumour grade, number of positive nodes, ER status, HER2 status, Ki67 status and mode of detection | PREDICT method (Multivariable Cox regression models) | Online /smartphone app | https://oncoassist.com/ |
| Oncotype IQ [31] | HC | 643 | Do I have aggressive disease? Do I need radiation? Do I need surgery? Do I need chemo? What stage is my cancer? | HER2-, ER+, PN | OncoType DX | Online | https://online.genomichealth.com |
| DESIREE [32] | HC/P | 400 | What are the available therapy options? | Medical imaging, biological and genetic data, diagnostic and biomarkers, risk factors, environmental or social aspects, clinical trials | Image processing, ontology and datamining | Online | http://www.desiree-project.eu/ |
| CancerMath [33] | HC/P | 779,999 | Prediction of survival at 15 years with different treatment options | SEER, HER-2, tumour size, nodal, tumour phenotype, and grade | Statistical algorithms | Online | http://www.lifemath.net/cancer/ |
| CTS5 Calculator [34] | HC/P | 4000+ | Prediction of survival at 10 years with different treatment options | Tumour size, tumour grade, patient age, and number of nodes | Statistical algorithms | Online | www.cts5-calculator.com/ |
| Residual Cancer Burden Calculator [35] | HC/P | 5000+ | Prognostic for event-free and distant relapse-free survival | Primary tumour bed area, percentage of cancer cellularity, percentage of cancer that is in situ disease, lymph nodes, number of positive lymph nodes, and diameter of largest metastasis | Statistical algorithms | Online | http://www3.mdanderson.org/app/medcalc/index.cfm?pagename=jsconvert3 |
* BC: breast cancer, P: patient-oriented interface, HC: Healthcare professionals’ interface, PN: Positive Nodes, HRS: hormone receptors status, CDSS: Clinical Decision Support System.