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. 2020 Feb 10;10(2):266. doi: 10.3390/biom10020266

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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LpxA-UDP-GlcNAc binding cavity volume and shape analysis. The substrate-binding cavity is enveloped with a smooth surface between adjacent monomers A and B. The grey color represents the hydrophobic region and red color represents the hydrophilic region in different orthologues such as (a) P. aeruginosa LpxA dimer (light salmon for monomer A and dark salmon for monomer B), (b) E. coli LpxA dimer (dark brown for monomer A and light brown for monomer B), (c) B. fragilis LpxA dimer (light magenta for monomer A and dark magenta for monomer B), (d) H. pylori LpxA dimer (light blue for monomer A and dark blue for monomer B), (e) L. interrogans LpxA dimer (light green for monomer A and dark green for monomer B), (f) A. baumannii LpxA dimer (light yellow for monomer A and dark yellow for monomer B), and (g) B. thailandensis LpxA dimer (light brown for monomer A and dark brown for monomer B).