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. 2020 Jan 28;12(2):306. doi: 10.3390/cancers12020306

Figure 4.

Figure 4

Combination of prexasertib and adavosertib enhances DNA breaks and aneuploidy. (a) γ-H2AX-positive foci in CAL27 and FaDu cell lines, 72 h after treatment with vehicle or drugs at concentrations indicated; (b,c) representative histograms from single runs of FACS analysis of CAL27 and FaDu cells from short term (48 h) (b) and long term (12 days) (с) treatment with vehicle, or drugs indicated; (d) quantification of cell cycle compartmentalization changes, averaged from three repetitions of experiments shown in (b), (c). All graphs: *, p ≤ 0.05; **, p ≤ 0.01; ***, p ≤ 0.001 relative to vehicle controls.